Design and Synthesis of Thiadiazole Derivatives as Antidiabetic Agents

Thiadiazole compounds have versatile activities such as anti-microbial, anti-inflammatory, anticancer, etc. Present study involves design of thiadiazole compounds as antidiabetic agent using docking studies. The designed molecules were synthesized and subjected to antidiabetic activity by in vitro and in vivo method. Compound TD7 was found to show potent antidiabetic activity in alloxan induced diabetes rat model. Molecular docking revealed that synthesized derivatives and target proteins were actively involved in binding and had significant correlation with biological activity. *Corresponding author: Prasanna A Datar, Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune, India, Tel: +91 9823161187; E-mail: [email protected] Received March 26, 2014; Accepted April 26, 2014; Published April 28, 2014 Citation: Datar PA, Deokule TA (2014) Design and Synthesis of Thiadiazole Derivatives as Antidiabetic Agents. Med chem 4: 390-399. doi:10.4172/21610444.1000170 Copyright: © 2014 Datar PA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.